Acne Vulgaris Discussions and Research

A new study published in the journal Dermatologic Therapy (2008 Mar-Apr;21(2):86-95) discusses the latest developments in the treatments available for acne. Of great concern recently has been the emergence of antibiotic resistance and the implications of this for the use of topical antibiotics.

In the study by Drs. Katsambas & Dessinioti from the University of Athens Department of Dermatology, treatments alternatives such as low-dose long-term isotretinoin are discussed. Here is an excerpt:

Topical retinoids, benzoyl peroxide, azelaic acid, and topical and oral antibiotics remain the milestone of treatment for mild to moderate acne vulgaris. Oral isotretinoin is useful for the treatment of severe nodular acne, treatment-resistant acne, and acne with a risk of physical or psychological scarring. Hormonal treatment in female acne is useful in resistant or late-onset acne.

With increasing concerns regarding teratogenicity of isotretinoin and increasing antibiotic resistance, there is a clear need for therapeutic alternatives to these long-used treatments. Research in the pathogenesis of acne has allowed for new therapies and future perspectives regarding acne to evolve. They include low-dose long-term isotretinoin regimens, insulin-sensitizing agents, 5alpha-reductase type 1 inhibitors, topical photodynamic therapy, new combination formulations, dietary interventions, and antiinflammatory agents such as lipoxygenase inhibitors.

Hopefully as we come to develop a better understanding of the pathogenesis of acne we can tailor even better treatment methods for this common and trouble skin disorder.

This entry was posted on Wednesday, November 19th, 2008 at 8:28 pm and is filed under Light Based Therapy and Laser. You can follow any responses to this entry through the RSS 2.0 feed. Responses are currently closed, but you can trackback from your own site.